What's New in Endocrinology?


New Medications on the Block:

GO to etc HOME Long acting insulins such as NPH, Lente, and Ultra-Lente are very good for controlling the "basal" or "non-eating" parts of the day for all people with type 1 Diabetes, and for many with type 2 Diabetes as well. However, not all is rosy. These insulins can have erratic, rather than smooth curves of action, most don't last truly all day long, and even under the best of circumstances,
Who Are We? have higher peaks at one point than another. It would be nice to have an insulin that was truly once per day,  worked steadily at a certain pace, and didn't have peaks or valleys  - anticipated or not. . . . .
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Enter insulin GLARGINE, (brand name LANTUS) produced by Aventis (formerly Hoescht-Marion-Roussel). This insulin works in the following manner:

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  • In 2/3s to 3/4s of patients, it is a once per day insulin. In the others - you must use it twice per day - just as with the former NPH or Lente - however - since the way this insulin works is so much more predictable and smooth - its still worth it for almost everybody who needs long acting insulin - even if its needed twice per day
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  • It controls the non-eating (basal) part of the day's insulin requirements
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  • GLARGINE Can't be mixed with other insulins - it needs to be injected by itself
  • is CLEAR rather than Cloudy (we had always been able to teach people - with some reservations, of course, that if your insulin is CLEAR - it's short acting - - - - - if CLOUDY it's long-acting. GLARGINE will now invalidate that "shortcut", too bad - but not the worst thing in the world)

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  • Slight stinging on injection

  • Doesn't take the place of short-acting insulins (Of course, this was not expected to be the case - but I mention it here for safety's sake - one should never stop taking a short acting insulin simply because of a change in a long acting insulin, and vice-versa as well)

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Improvement and Reason for using it:

  • Improved Diabetes control, around the clock, with less hypoglycemia, causing less Diabetes complications later on

Other things to remember:

  • It is available now

  • Care must be exercised not to mix it with any other insulin, or to confuse it with a short acting insulin because of its clear appearance

  • For people with type 2 Diabetes, this will NOT replace oral medications (at least in most instances) but rather supplement them


 

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